HPE ProLiant ML110 Gen10 + m.2 Samsung 970 EVO 2 TB

Is this compatible?

HPE ProLiant ML110 Gen10
ASUS HYPER M.2 X16 CARD (4x M.2 SSD)
m.2 Samsung 970 EVO 2 TB

I want to boot from usb key (ESXi) and SSD use as storage for virtual computers.

Thank You
Peter, IT admin of primary school